This listing was posted on jobRxiv.
Scientist Clinical Biomarker Lab UK Flow Cytometry
Location:
Oxford, Oxon
Description:
The Role: Joining Moderna offers the unique opportunity to be part of a pioneering team that's revolutionizing medicine through mRNA technology with a diverse pipeline of development programs across various diseases. As an employee you'll be part of a continually growing organization working alongside exceptional colleagues and strategic partners worldwide contributing to global health initiatives. Moderna's commitment to advancing the technological frontier of mRNA medicines ensures a challenging and rewarding career experience with the potential to make a significant impact on patients' lives worldwide.Moderna's mission is to establish a leading-edge research, development, and manufacturing facility at Harwell as part of a long-term commitment to onshore mRNA vaccine production for respiratory diseases. This initiative will create a multitude of highly skilled jobs and foster collaboration with academic, NHS, and government partners across the UK. We're looking for global experts eager to join us in this endeavour, contributing to a future where access to life-saving vaccines is a reality for all.Moderna is seeking a talented, experienced, and motivated Scientist to join the Clinical Flow Cytometry group based in Harwell, Oxfordshire, to serve as a scientific and technical expert for flow cytometry assay validation and clinical testing to support clinical programs across multiple therapeutic areas. The Scientist will work with a team to develop cell-based flow cytometry assays, perform fit-for-purpose validations, and assay clinical samples to return high-quality data for clinical trials conducted by Moderna. You will be an integral part in applying high parameter flow cytometric assays using a spectral cytometer to generate key clinical data to drive clinical trial decisions. The candidate will have broad knowledge of best practices in clinical flow cytometry with proven experience. The Scientist will effectively communicate across multi-disciplinary teams to contextualize program needs and effectively plan studies to meet data rigor expectations and deliver data within required timelines. In addition, the candidate will be involved in the training of less experienced team members when and where needed to perform analytical work and maintain clinical testing integrity and continuity. Here's What You'll Do: Your key responsibilities will be: Work with a team of scientists to perform high parameter spectral flow cytometry assays on clinical trial samples in adherence to GCLP guidelines to generate key data for clinical decision making. Acting as a study lead, plan, organize, and execute assay qualification and fit-for-purpose validation studies. Run experiments independently and accurately analyze and present data. Conduct ex vivo experimental work for functional profiling of immune responses. Coordinate within the team to plan and execute clinical sample testing under GCLP guidelines. Working across functions and matrix throughout the organization, you will engage with Biomarker leads to select appropriate assays to meet biomarker strategy goals, particularly as related to assay readiness for clinical deployment. Work with the Associate Director of Clinical Flow Cytometry and the team to establish timelines for analytical testing including study start-up, clinical testing, study wrap-up, and data transfer. Author reports including SOPs, analytical study plans, analytical study reports, as needed. Work with the team to refine documentation procedures and workflows aligned to clinical cytometry industry expectations and regulations. Identify and resolve issues in flow assays, employ mitigation strategies, and escalate issues, as needed. Identify and work on optimizing processes to alleviate bottlenecks in current workflows to increase efficiency. Educate and train less experienced staff in flow cytometry, technical detailed execution of assays, and documentation requirements and workflows where appropriate. Research scientific and technical literature to propose, test, and implement innovative solutions that may be applicable to the laboratory. Occasionally the job may require overtime work or weekend shifts. Travel for attending training, technical conferences, and exhibits as required. Your responsibilities will also include: Represent the bioanalytical function on project teams and present results, data interpretation, timelines, etc., at project meetings. Collaborate with internal and external stakeholders to evaluate new bioanalytical technologies and solutions to support challenging project requests. The key Moderna Mindsets you'll need to succeed in the role: Prioritize the platform: Emphasize the importance of the platform over any single product, ensuring a holistic approach to bioanalytical projects. Obsess over learning: Continuously seek new knowledge and advancements in cell-based and bio-analytical test methods to maintain cutting-edge expertise and support clinical phase studies. Here's What You'll Bring to the Table: Ph.D. with >2 years of high parameter flow cytometry experience, or MS with >6 years of high parameter flow cytometry experience Strong level of understanding in designing and executing immune-related studies and assays. Knowledge of best practices in flow cytometric assays for generating high quality data In depth experience in performing complex multiparameter flow cytometry assays including immunophenotyping and ex vivo cell-based assays for functional profiling such as intracellular cytokine staining, cell activation and proliferation, etc. Experience with flow cytometry assay fit-for-purpose validation applicable for intended use of data is desirable. Experience with processing human PBMC from whole blood sample is highly desirable. Experience in clinical lab setting is desirable. Experience working in a regulated lab is preferred. The ability to work in a cross-functional work environment with effective communication skills to contextualize program needs and effectively plan studies to meet data rigor expectations and deliver data within required timelines. Excellent organizational and planning (project management) skills. Flexibility with changing priorities and urgent project requests Experience in high parameter data analysis using software such as FCS Express, OMIQ, Flowjo Experience in a bio-pharmaceutical or related industrial experience is desired. Experience with LIMS and electronic notebook (ELN) is desired. This position is site-based, requiring you to be at Moderna's site full-time. This position is not eligible for remote work. Moderna offers personalized benefit programs and well-being resources as unique as our global workforce so employees can do their best work. We recognize and appreciate your diverse needs and interests and do our best to support you at work and at home with: Quality healthcare and insurance benefits Lifestyle Spending Accounts to create your own pathway to well-being Free premium access to fitness, nutrition, and mindfulness classes Family planning and adoption benefits Generous paid time off, including vacation, bank holidays, volunteer days, sabbatical, and a discretionary year-end shutdown Educational resources Savings and investments Location-specific perks and extras! The benefits offered may vary depending on the nature of your employment with Moderna and the country where you work. About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute and make a meaningful impact.If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.Moderna is a smoke-free, alcohol-free and drug-free work environment.Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We're focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.Moderna is committed to offering reasonable accommodations or adjustments to qualified job applicants with disabilities. Any applicant requiring an accommodation or adjustment in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied shouldcontact the Accommodations and Adjustments team at XXXX@modernatx.com.
Company:
Moderna
Posted:
June 29 on jobRxiv
Visit Our Partner Website
This listing was posted on another website. Click here to open: Go to jobRxiv
Important Safety Tips
- Always meet the employer in person.
- Avoid sharing sensitive personal and financial information.
- Avoid employment offers that require a deposit or investment.
To learn more, visit the Safety Center or click here to report this listing.