This listing was posted on jobRxiv.
Scientist, Neuroscience - Fixed Term Contract (12 months)
Location:
London, Gt Lon
Description:
Job DescriptionOur company has a rapidly growing interdisciplinary team of scientists in London and exciting plans to expand our London presence, initially at the Francis Crick Institute as part of our 'Skylab' expansion in 2024, and from 2027 in our new 'state of art' and fully integrated Research and Discovery Center at the hub of London's knowledge Quarter, which will be home to approximately 180 scientists alongside other colleagues in discovery research, clinical, regulatory and business roles, including marketing, finance and administration.Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines through improving our understanding of how our potential new therapies and medicines work at a cellular and molecular level in the patients we serve.Our London Discovery Centre is seeking a passionate and driven candidate to join our Neuroscience team based at the London Bioscience Innovation Centre (LBIC) in St. Pancras, London. The candidate for this Scientist position will contribute to cutting-edge discovery biology research, investigating age-related neurodegeneration with a focus on disease-associated protein clearance, oxidative and ER Stress.You will join a highly collaborative, multi-disciplinary research team and collaborate and interact with scientists across groups within our company, who have extensive experience in aspects of biology from different therapeutic areas, in vitro pharmacology, chemistry, and data science. Responsibilities include but are not limited to: • Perform in vitro experiments to investigate disease-associated protein levels as well as mechanisms and pathways of oxidative stress and ER stress to support the development of early potential drug candidates• Contribute to the design and implementation of novel disease-relevant in vitro models in a range of CNS-derived cell types• Keep up to date with advancements in the fields of disease-associated protein clearance, oxidative stress and/or ER stress research and apply relevant knowledge to enhance experimental approaches• Collaborating with members from other functional areas, including medicinal chemistry, in vivo and in vitro pharmacology, imaging, genetics, and translational sciences to drive progress• Timely write-up of reports and data• Oral and written communication of data in a clear and concise manner to the appropriate teams and stakeholders Education & Experience Minimum Requirements: • BSc or MSc, in a life sciences discipline (Neuroscience, Biochemistry, or related discipline) with pharmaceutical industrial experience. Required Experience and Skills: • Experience in cell culture techniques and working with primary cells, cell lines, and/or iPSCs• Experience in molecular biology and microscopy/cellular imaging techniques• Excellent attention to detail in experimental design and data analysis• Strong interpersonal, verbal, and written communication skills• Ability to thrive within a matrixed organisation and collaborate with cross-functional teams Experience in any of the following would be advantageous: • Scientific understanding of mechanisms of neurodegeneration• Cellular and molecular biology techniques• Cell imaging and microscopy including high content imaging• Knowledge of drug discovery and assay development• Exposure to high throughput instrumentation, including plate readers and liquid handling instrumentationCurrent Employees apply HERECurrent Contingent Workers apply HERE Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Project Temps (Fixed Term) Relocation: VISA Sponsorship: Travel Requirements: Flexible Work Arrangements: Not Applicable Shift: Valid Driving License: Hazardous Material(s): Job Posting End Date: 10/18/2024 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Company:
Merck
Posted:
October 12 on jobRxiv
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